A Review on Zebrafish (Danio rerio) and Zebrafish embryo as a tool to study pyrethroid compounds’ toxicity

Now Zebrafish is the best animal model proved to study various molecules, in addition to understand biological functions, also to know the mechanism underlying the effect of any compound which can contribute to therapeutic discoveries. Pyrethroids are a class of man-made pesticides similar with the naturally available pesticide pyrethrum, which is produced by Chrysanthemum flowers. Pyrethroid insecticides are very commonly used residential and agricultural insecticides. As per scientific data available, it is observed that insecticides as well as pesticides have been involved in several neurological disorders in experimental animals and in humans too. Never the less, some data gap exists as their toxicity assessment is complex. Reviewing the valuable researches on effects of pyrethroid compound’s toxicity on Zebrafish provides the useful information and proves that the Zebrafish are excellent model for toxicity studies. Nevertheless, comparatively less studies there on Pyrethroid’s developmental neurotoxicity on the developing Zebrafish embryo. Concerning about pyrethroids, it can be assumed that, there may be higher risk of using these pesticides than currently acknowledged, as general population is using them extensively and in unsupervised manner. The precautionary step will be to guide our action on usage of pyrethroids to prevent undesirable consequences. Further research on alternatives to synthetic pyrethroids may need support from authorised institutes or government.